2. Academic Validation
  3. The Biosynthesis Related Enzyme, Structure Diversity and Bioactivity Abundance of Indole-Diterpenes: A Review

The Biosynthesis Related Enzyme, Structure Diversity and Bioactivity Abundance of Indole-Diterpenes: A Review

  • Molecules. 2022 Oct 13;27(20):6870. doi: 10.3390/molecules27206870.
Yong Hou 1 2,  Meiying Chen 1 2,  Zhaocui Sun 1 2,  Guoxu Ma 1 2,  Deli Chen 2,  Haifeng Wu 2,  Junshan Yang 2,  Yihang Li 1 2,  Xudong Xu 1 2
Affiliations

Affiliations

  • 1 Yunnan Key Laboratory of Southern Medicine Utilization, Yunnan Branch, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Jinghong 666100, China.
  • 2 Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China.
PMID: 36296463 DOI: 10.3390/molecules27206870
Abstract

Indole diterpenes are a large class of secondary metabolites produced by fungi, possessing a cyclic diterpenoid backbone and an indole moiety. Novel structures and important biological activity have made indole diterpenes one of the focuses of synthetic chemists. Although the discovery, identification, structural diversity, biological activity and especially structure-activity relationship of indole diterpenes have been reported in some papers in recent years, they are absent of a systematic and comprehensive analysis, and there is no elucidation of Enzymes related to this kind of natural product. Therefore, it is necessary to summarize the relevant reports to provide new perspectives for the following research. In this review, for the first time, the function of related synthases and the structure-activity relationship of indole diterpenes are expounded, and the recent research advances of them are emphasized.

Keywords

bioactivity; indole diterpene; structure–activity relationship; synthase.

Figures
Products