2. Academic Validation
  3. Dichapetalins from the Twigs of Dichapetalum longipetalum with Cytotoxic Activities

Dichapetalins from the Twigs of Dichapetalum longipetalum with Cytotoxic Activities

  • J Nat Prod. 2023 Jan 27;86(1):209-221. doi: 10.1021/acs.jnatprod.2c00971.
Bin Zhou 1 2,  Xin-Hua Gao 1,  Min-Min Zhang 1,  Hong-Chun Liu 1 2,  Jian-Min Yue 1 2
Affiliations

Affiliations

  • 1 State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, People's Republic of China.
  • 2 Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, Shandong 264117, People's Republic of China.
PMID: 36583957 DOI: 10.1021/acs.jnatprod.2c00971
Abstract

Continued efforts to expand the structural diversity of dichapetalins and explore further the cytotoxic structure-activity relationships have led to the isolation of 17 undescribed analogues, dichapelonins A-Q (1-17), and three known compounds (18-20) from the twigs of Dichapetalum longipetalum. Compounds 1-17 comprise five compound classes as classified by varied C6-C2 conjugates at the A ring of the 13,30-cyclodammarane skeleton, and their structures were determined by spectroscopic data analysis, experimental electronic circular dichroism measurements, and X-ray crystallography. Biological tests revealed compounds 1-7 with a phenyl-butadiene appendage to be the most potent cytotoxic compound type of those evaluated.

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