2. Academic Validation
  3. Regulatory effect of sericin protein in inflammatory pathways; A comprehensive review

Regulatory effect of sericin protein in inflammatory pathways; A comprehensive review

  • Pathol Res Pract. 2023 Mar:243:154369. doi: 10.1016/j.prp.2023.154369.
Sina Rahimpour 1,  Hadi Jabbari 2,  Hajar Yousofi 3,  Arian Fathi 4,  Shiva Mahmoodi 5,  Mohammad Javad Jafarian 6,  Navid Shomali 7,  Siamak Sandoghchian Shotorbani 8
Affiliations

Affiliations

  • 1 Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
  • 2 Department of Chemistry, Payame Noor University, P.O. Box 19395-4697, Tehran, Iran.
  • 3 Faculty of paramedical science, Islamic Azad University Tehran Medical Branch, Tehran, Iran.
  • 4 School of Pharmacy, Shiraz university of medical science, Shiraz, Iran.
  • 5 School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
  • 6 School of Medicine, Babol University of Medical Sciences, Babol, Iran.
  • 7 Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: shomali.navid@yahoo.com.
  • 8 Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: sandoghchians@tbzmed.ac.ir.
PMID: 36812737 DOI: 10.1016/j.prp.2023.154369
Abstract

Sericin protein is a type of protein derived from silk cocoons. Sericin hydrogen bonds cause adhesion to the silk cocoon. This substance contains a large amount of serine Amino acids in its structure. At first, the medicinal properties of this substance were unknown, but today many properties have been discovered for this substance. The unique properties of this substance have made it widely used in the pharmaceutical and cosmetic industries. The applications of Sericin in pharmacy are as follows. Sericin is used to repair wounds by producing collagen. Other uses for the drug include anti-diabetic, anti-cholesterol, metabolic modulator, anti-tumor, heart protection, antioxidant, Antibacterial, wound healing, cell proliferation, UV protection, freezing, and skin moisturizing. The physicochemical properties of Sericin have attracted the attention of pharmacists and their widespread use in the production of drugs and treatment of diseases. One of the critical and unique properties of Sericin is its anti-inflammatory property. In this article, this property of Sericin is discussed in detail, and according to the experiments performed by pharmacists, this substance has shown a significant effect in eliminating inflammation. This study aimed to evaluate the impact of Sericin protein in relieving inflammation.

Keywords

Immunoglobulin; Inflammation; Leukocyte; Sericin; Silk protein.

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