2. Academic Validation
  3. A Recombinant Parathyroid Hormone-Related Peptide Locally Applied in Osteoporotic Bone Defect

A Recombinant Parathyroid Hormone-Related Peptide Locally Applied in Osteoporotic Bone Defect

  • Adv Sci (Weinh). 2023 May 25;e2300516. doi: 10.1002/advs.202300516.
Yi Wang 1,  Yingkun Hu 1,  Shenghui Lan 2 3,  Zhe Chen 1,  Yufeng Zhang 4,  Xiaodong Guo 5,  Lin Cai 1,  Jingfen Li 1
Affiliations

Affiliations

  • 1 Zhongnan Hospital of Wuhan University, Donghu Road 169, Wuhan, 430071, P. R. China.
  • 2 Department of Orthopaedics, The Eighth People's Hospital, Jiangsu University, Shanghai, 200235, P. R. China.
  • 3 Department of Orthopaedics, Xuhui Branch of The Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, 200233, P. R. China.
  • 4 Department of Orthopedics, The Second Hospital of Tianjin Medical University, Tianjin, 300211, P. R. China.
  • 5 Department of Orthopedics, Union Hospital Tongji Medical College, Huazhong University of Science and Technology, Jiefang Road 1277, Wuhan, 430022, P. R. China.
PMID: 37229774 DOI: 10.1002/advs.202300516
Abstract

The local application of drug-loaded bioactive scaffold Materials is one of the important directions to solve the clinical problem of osteoporotic (OP) bone defects. This study retains the advantages of drug loading and mechanical properties of natural 3D bioactive scaffolds. The scaffolds are functionally modified through chemical and self-assembly approaches with application of polydopamine (PDA) nanoparticles and parathyroid hormone-related peptide-1 (PTHrP-1) for efficient local drug loading. This study investigates the effects of the novel bioactive scaffolds on ossification, osteoclastogenesis, and macrophage polarization. This work elucidates the effects of the scaffolds in regulating osteoclastic activity and new bone formation in vitro. Further studies on the establishment and repair of OP bone defects in small Animals are conducted, and the potential of natural bioactive porous scaffold Materials to promote the repair of OP bone defects is initially verified. The preparation of safe and economical anti-OP bone repair material provides a theoretical basis for clinical translational applications.

Keywords

bioactive scaffold; bone remodeling; osteoblasts; osteoclasts; osteoporotic bone defect; parathyroid hormone-related peptide.

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