2. Academic Validation
  3. Antioxidant and α-glucosidase inhibitory activities of compound isolated from Stachytarpheta jamaicensis (L) Vahl. leaves

Antioxidant and α-glucosidase inhibitory activities of compound isolated from Stachytarpheta jamaicensis (L) Vahl. leaves

  • Sci Rep. 2023 Oct 30;13(1):18597. doi: 10.1038/s41598-023-45357-z.
Sri Fatmawati 1,  Fithrotul Auwaliyah 2,  Yuliana 2,  Nur Hasanah 2,  Devi Anggraini Putri 2 3,  Healthy Kainama 4,  Muhammad Iqbal Choudhary 5
Affiliations

Affiliations

  • 1 Department of Chemistry, Faculty of Science and Data Analytics, Institut Teknologi Sepuluh Nopember, Jawa Timur, Surabaya, 60111, Indonesia. fatma@chem.its.ac.id.
  • 2 Department of Chemistry, Faculty of Science and Data Analytics, Institut Teknologi Sepuluh Nopember, Jawa Timur, Surabaya, 60111, Indonesia.
  • 3 Department of Medical Laboratory Technology, Sekolah Tinggi Ilmu Kesehatan Ngudia Husada Madura, Bangkalan, 69116, Indonesia.
  • 4 Laboratory of Chemistry, Chemistry Education Study Program, Faculty of Teacher Training and Educational Sciences, Pattimura University, Ambon, 97234, Indonesia.
  • 5 H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan. iqbal.choudhary@iccs.edu.
PMID: 37903808 DOI: 10.1038/s41598-023-45357-z
Abstract

Stachytarpheta jamaicensis is one of the folk medicines used for the treatment of diabetes in Ambon, Indonesia, but there are limited studies on the bioactivities of its constituents. This study aims to assess the antioxidant and antidiabetic activities of four extracts of S. jamaicensis leaves extracted using several Solvents. Bioassay guided fractionation on each extract establishes for exploring S. jamaicensis leaves active compounds. The antioxidant was evaluated using the DPPH and ABTS methods, while the α-glucosidase inhibitory was carried out in vitro assay. The results showed that the methanol extract of S. jamaicensis leaves displays inhibition of DPPH, ABTS and α-glucosidase activity compared to Other solvent extracts. Furthermore, 6β-hydroxyipolamiide was successfully isolated from the methanol extract of S. jamicensis leaves which was reported to have α-glucosidase inhibitory activity with an IC50 of 539.17 μg/mL. Based on the results, S. jamaicensis could be recommended as an antioxidant and antidiabetic agent.

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