2. Academic Validation
  3. Discovery of new α-glucosides, antiglycation agent, and in silico study of 2-(3,4-dihydroxyphenyl)-7,8-dihydroxy-3-methoxy-4H-chromen-4-one isolated from Pistacia chinensis

Discovery of new α-glucosides, antiglycation agent, and in silico study of 2-(3,4-dihydroxyphenyl)-7,8-dihydroxy-3-methoxy-4H-chromen-4-one isolated from Pistacia chinensis

  • Heliyon. 2024 Mar 5;10(5):e27298. doi: 10.1016/j.heliyon.2024.e27298.
Tareq Abu-Izneid 1,  Abdur Rauf 2,  Zuneera Akram 3,  Saima Naz 4,  Abdul Wadood 5,  Naveed Muhammad 6,  Chandni Hayat 5,  Yahya S Al-Awthan 7,  Omar S Bahattab 7
Affiliations

Affiliations

  • 1 Pharmaceutical Sciences Program, College of Pharmacy, Al Ain University, Al Ain, 64141, United Arab Emirates.
  • 2 Department of Chemistry, University of Swabi, Swabi, Anbar, Khyber Pakhtunkhwa, Pakistan.
  • 3 Department of Pharmacology, Faculty of Pharmaceutical Sciences, Baqai Medical University, Karachi, Pakistan.
  • 4 Institute of Biotechnology & Microbiology, Bacha Khan University Charsadda, Charsadda, Khyber Pakhtunkhwa, Pakistan.
  • 5 Department of Biochemistry, Abdul Wali Khan University Mardan KPK, Pakistan.
  • 6 Department of Pharmacy, Abdul Wali Khan, University Mardan, Khyber Pakhtunkhwa, Pakistan.
  • 7 Department of Biology, Faculty of Science, University of Tabuk, Tabuk, 71491, Saudi Arabia.
PMID: 38495136 DOI: 10.1016/j.heliyon.2024.e27298
Abstract

Pistacia chinensis is locally practiced for treating diabetes, pain, inflammation, and erectile dysfunction. Therefore, the current studies subjected the crude extract/fractions and the isolated compound (2-(3,4-dihydroxyphenyl)-7,8-dihydroxy-3-methoxy-4H-chromen-4-one) to α-glucosidase inhibitor and anti-glycation activities. The development of long-term complications associated with diabetes is primarily caused by chronic hyperglycemia. Regarding α-glucosidase, the most significant inhibitory effect was observed with compound 1 (93.09%), followed by the methanolic extract (80.87%) with IC50 values of 45.86 and 86.32 μM. The maximum anti-glycation potential was shown by an isolated compound 1 followed by methanolic extract with effect inhibition of 90.12 and 72.09, respectively. Compound 1 is expected to have the highest gastrointestinal absorption rate, with a predicted absorption rate of 86.156%. This indicates oral suitability. The compound 1 is expected to have no harmful effects on the liver. In addition, our docking results suggest that alpha-glucosidase and isolated compounds showed strong interaction with ILE821, GLN900, and ALA901 residues, along with a -11.95 docking score.

Keywords

Antiglycation; Docking analysis; Pistacia chinensis, flavonoid; α‐glucosides.

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