2. Academic Validation
  3. A noradrenergic pathway for the induction of pain by sleep loss

A noradrenergic pathway for the induction of pain by sleep loss

  • Curr Biol. 2024 Jun 17;34(12):2644-2656.e7. doi: 10.1016/j.cub.2024.05.005.
Qianqian Lou 1,  Hong-Rui Wei 1,  Danyang Chen 1,  Yuzhuo Zhang 2,  Wan-Ying Dong 1,  Sen Qun 3,  Di Wang 4,  Yanli Luo 5,  Zhi Zhang 6,  Yan Jin 7
Affiliations

Affiliations

  • 1 Department of Anesthesiology, The First Affiliated Hospital of USTC, Hefei National Laboratory for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China.
  • 2 Department of Physiology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230022, China.
  • 3 Stroke Center and Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China.
  • 4 Department of Anesthesiology, The First Affiliated Hospital of USTC, Hefei National Laboratory for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China. Electronic address: di.wang@ustc.edu.cn.
  • 5 Department of Psychological Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China. Electronic address: luoluoyanli@163.com.
  • 6 Department of Anesthesiology, The First Affiliated Hospital of USTC, Hefei National Laboratory for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China; The Center for Advanced Interdisciplinary Science and Biomedicine, Institute of Health and Medicine, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China; Department of Biophysics and Neurobiology, CAS Key Laboratory of Brain Function and Disease, University of Science and Technology of China, Hefei 230026, China. Electronic address: zhizhang@ustc.edu.cn.
  • 7 Stroke Center and Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China; Department of Biophysics and Neurobiology, CAS Key Laboratory of Brain Function and Disease, University of Science and Technology of China, Hefei 230026, China. Electronic address: jinyan@ustc.edu.cn.
PMID: 38810638 DOI: 10.1016/j.cub.2024.05.005
Abstract

An epidemic of sleep loss currently affects modern societies worldwide and is implicated in numerous physiological disorders, including pain sensitization, although few studies have explored the brain pathways affected by active sleep deprivation (ASD; e.g., due to recreation). Here, we describe a neural circuit responsible for pain sensitization in mice treated with 9-h non-stress ASD. Using a combination of advanced neuroscience methods, we found that ASD stimulates noradrenergic inputs from locus coeruleus (LCNA) to glutamatergic neurons of the hindlimb primary somatosensory cortex (S1HLGlu). Moreover, artificial inhibition of this LCNA→S1HLGlu pathway alleviates ASD-induced pain sensitization in mice, while chemogenetic activation of this pathway recapitulates the pain sensitization observed following ASD. Our study thus implicates activation of the LCNA→S1HLGlu pathway in ASD-induced pain sensitization, expanding our fundamental understanding of the multisystem interplay involved in pain processing.

Keywords

S1HL; active sleep deprivation; chemogenetic inhibition; neural circuit; noradrenaline; pain sensitization.

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