2. Academic Validation
  3. Synthesis and Biological Activities of Scleropentaside D

Synthesis and Biological Activities of Scleropentaside D

  • J Org Chem. 2024 Jun 21;89(12):9098-9102. doi: 10.1021/acs.joc.4c00755.
Nai-Li Fan,  Lu Zhang,  Chun-Yan Peng,  Wei-Lin Liao,  Xiang-Guo Hu 1
Affiliations

Affiliation

  • 1 National Engineering Research Center for Carbohydrate Synthesis, Jiangxi Normal University, Nanchang, 330022, China.
PMID: 38861461 DOI: 10.1021/acs.joc.4c00755
Abstract

We report the first total synthesis of scleropentaside D, a unique C-glycosidic ellagitannin, from the ketal derivative of scleropentaside A employing site-selective O4-protection of C-acyl glycoside and copper-catalyzed oxidative coupling reaction of galloyl groups as the key steps. Our study confirms the proposed structure of this natural product, scleropentaside D, and demonstrates its effectiveness as an inhibitor of α-glycosidase.

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