2. Academic Validation
  3. Nutrient-delivery and metabolism reactivation therapy for melanoma

Nutrient-delivery and metabolism reactivation therapy for melanoma

  • Nat Nanotechnol. 2024 Jun 11. doi: 10.1038/s41565-024-01690-6.
Yang Chen # 1 2,  Chaochao Wang # 1 2,  Yelin Wu # 1,  Ya Wang 2,  Yun Meng 1,  Fan Wu 2,  Huilin Zhang 2 3,  Yuen Yee Cheng 4,  Xingwu Jiang 2,  Jieyun Shi 1,  Huiyan Li 2,  Peiran Zhao 2,  Jinfeng Wu 5,  Bin Zheng 6,  Dayong Jin 7 8,  Wenbo Bu 9 10 11
Affiliations

Affiliations

  • 1 Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Tongji University Cancer Center, School of Life Sciences and Technology, Tongji University, Shanghai, P. R. China.
  • 2 Department of Materials Science and State Key Laboratory of Molecular Engineering of Polymers, Academy for Engineering and Technology, Fudan University, Shanghai, P. R. China.
  • 3 Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, P. R. China.
  • 4 Institute for Biomedical Materials and Devices (IBMD), Faculty of Science, University of Technology Sydney, Sydney, New South Wales, Australia.
  • 5 Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, P. R. China. jinfengwu@fudan.edu.cn.
  • 6 Cedars-Sinai Cancer Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • 7 Institute for Biomedical Materials and Devices (IBMD), Faculty of Science, University of Technology Sydney, Sydney, New South Wales, Australia. dayong.Jin@uts.edu.au.
  • 8 Eastern Institute for Advanced Study, Eastern Institute of Technology, Ningbo, P. R. China. dayong.Jin@uts.edu.au.
  • 9 Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Tongji University Cancer Center, School of Life Sciences and Technology, Tongji University, Shanghai, P. R. China. wbbu@fudan.edu.cn.
  • 10 Department of Materials Science and State Key Laboratory of Molecular Engineering of Polymers, Academy for Engineering and Technology, Fudan University, Shanghai, P. R. China. wbbu@fudan.edu.cn.
  • 11 Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, P. R. China. wbbu@fudan.edu.cn.
  • # Contributed equally.
PMID: 38862714 DOI: 10.1038/s41565-024-01690-6
Abstract

To fulfil the demands of rapid proliferation, tumour cells undergo significant metabolic alterations. Suppression of hyperactivated metabolism has been proven to counteract tumour growth. However, whether the reactivation of downregulated metabolic pathways has therapeutic effects remains unexplored. Here we report a nutrient-based metabolic reactivation strategy for effective melanoma treatment. L-Tyrosine-oleylamine nanomicelles (MTyr-OANPs) were constructed for targeted supplementation of tyrosine to reactivate melanogenesis in melanoma cells. We found that reactivation of melanogenesis using MTyr-OANPs significantly impeded the proliferation of melanoma cells, primarily through the inhibition of glycolysis. Furthermore, leveraging melanin as a natural photothermal reagent for photothermal therapy, we demonstrated the complete eradication of tumours in B16F10 melanoma-bearing mice through treatment with MTyr-OANPs and photothermal therapy. Our strategy for metabolism activation-based tumour treatment suggests specific nutrients as potent activators of metabolic pathways.

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