2. Academic Validation
  3. Copper exposure induces trophoblast cell cuproptosis by up-regulating lnc-HZ11

Copper exposure induces trophoblast cell cuproptosis by up-regulating lnc-HZ11

  • Ecotoxicol Environ Saf. 2024 Aug:281:116641. doi: 10.1016/j.ecoenv.2024.116641.
Zhaodian Zheng 1,  Jing Fang 2,  Yanqiu Shen 2,  Chenyang Mi 3,  Zhongyan Xu 3,  Jingsong Zhao 3,  Weina Chen 3,  Ruining Han 4,  Qiong Lei 5,  Huidong Zhang 6
Affiliations

Affiliations

  • 1 Department of Toxicology, School of Public Health, Fujian Medical University, Fuzhou 350122, China; Research Center for Environment and Female Reproductive Health, the Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518033, China.
  • 2 Department of Toxicology, School of Public Health, Fujian Medical University, Fuzhou 350122, China.
  • 3 Research Center for Environment and Female Reproductive Health, the Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518033, China.
  • 4 Department of Obstetrics, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong Province, China. Electronic address: guyuansiyu@163.com.
  • 5 Department of Obstetrics, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong Province, China. Electronic address: leiqiong3861@qq.com.
  • 6 Research Center for Environment and Female Reproductive Health, the Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518033, China. Electronic address: zhanghd29@mail.sysu.edu.cn.
PMID: 38936053 DOI: 10.1016/j.ecoenv.2024.116641
Abstract

Copper pollution has attracted global environmental concern. Widespread Cu pollution results in excessive Cu accumulation in human. Epidemiological studies and animal experiments revealed that Cu exposure might have reproductive toxicity. Cuproptosis is a recently reported Cu-dependent and programmed cell death pattern. However, the mechanism by which copper exposure might cause cell Cuproptosis is largely unknown. We chose trophoblast cells as cell model and found that copper exposure causes trophoblast cell Cuproptosis. In mechanism, copper exposure up-regulates lnc-HZ11 expression levels, which increases intracellular Cu2+ levels and causes trophoblast cell Cuproptosis. Knockdown of lnc-HZ11 efficiently reduces intracellular Cu2+ levels and alleviate trophoblast cell Cuproptosis, which could be further alleviated by co-treatment with DC or TEPA. These results discover novel toxicological effects of copper exposure and also provide potential target for protection trophoblast cells from Cuproptosis in the presence of excessive copper exposure.

Keywords

Cu or Copper pollution; Cuproptosis; Lnc-HZ11; Trophoblast cells.

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    99.97%, Atox1/CCS Inhibitor