1. Academic Validation
  2. Unveiling FM-1088: A Breakthrough in Isoindolinone-Based Acaricide Development

Unveiling FM-1088: A Breakthrough in Isoindolinone-Based Acaricide Development

  • J Agric Food Chem. 2024 Aug 14;72(32):18045-18055. doi: 10.1021/acs.jafc.4c05027.
Dongdong Liu 1 2 Yixing Gao 1 Hongyan Pei 1 Jialin Ye 1 Haijing Hao 1 Jing Zhang 1 2 3 Lixin Zhang 1 2 3
Affiliations

Affiliations

  • 1 Institute of Functional Molecules, Shenyang University of Chemical Technology, Liaoning Province Key Laboratory of Green Functional Molecular Design and Development, Shenyang Key Laboratory of Targeted Pesticides, Shenyang 110142, China.
  • 2 School of Chemical Engineering, University of Science and Technology Liaoning, Anshan 114051, Liaoning, China.
  • 3 Metisa Biotechnology Co., Ltd., Nanning 530000, China.
Abstract

The increasing resistance of agricultural pests to existing acaricides presents a significant challenge to sustainable agriculture. Therefore, this study introduced FM-1088, a novel isoindolinone-based phenyl trifluoroethyl thioether derivative generated through an innovative design strategy combining bioisosterism and novel cyclization methods. We synthesized several compounds and evaluated their acaricidal efficacy against Tetranychus cinnabarinus in greenhouses and Panonychus citri in field settings. FM-1088 emerged as a standout candidate, demonstrating a lower median lethal concentration (LC50) of 0.722 mg/L compared to the commercial acaricide, cyetpyrafen. Notably, 30 days after application, FM-1088 showed a field control efficacy of 96.4% against P. citri, highlighting its potential for broader applications. The results underscore the utility of the isoindolinone scaffold in pesticide development, offering a promising solution to combat pest resistance with implications for enhanced crop protection and agricultural productivity. Future studies should explore the detailed mode of action of FM-1088 and its potential applicability across diverse agricultural settings, further confirming its role as a sustainable solution for pest management.

Keywords

acaricidal activity; chemical synthesis; pest resistance; structure−activity relationship; sustainable agriculture.

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