2. Academic Validation
  3. Specific Activation of Dopamine Receptor D1 Expressing Neurons in the PrL Alleviates CSDS-Induced Anxiety-Like Behavior Comorbidity with Postoperative Hyperalgesia in Male Mice

Specific Activation of Dopamine Receptor D1 Expressing Neurons in the PrL Alleviates CSDS-Induced Anxiety-Like Behavior Comorbidity with Postoperative Hyperalgesia in Male Mice

  • Mol Neurobiol. 2024 Aug 23. doi: 10.1007/s12035-024-04444-6.
Wang Wang 1 2,  Weizhen Liu 1 2,  Sufang Liu 3,  Dongxiao Duan 1,  Yajing Ma 4,  Zijuan Zhang 5,  Changsheng Li 6,  Yuanyuan Tang 7,  Zhiju Wang 8,  Ying Xing 9
Affiliations

Affiliations

  • 1 Department of Physiology and Neurobiology, School of Basic Medical Sciences, Zhengzhou University, No.100 Science Road, Gao-Xin District, Henan, 450001, Zhengzhou, China.
  • 2 The Academy of Medical Sciences of Zhengzhou University, Henan, 450001, Zhengzhou, China.
  • 3 Department of Biomedical Sciences, Texas A&M University College of Dentistry, Dallas, TX75246, USA.
  • 4 College of Biology and Food, Shangqiu Normal University, Shangqiu, 476000, China.
  • 5 School of Basic Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, 450046, China.
  • 6 Department of Anesthesiology, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
  • 7 School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, 453003, China.
  • 8 Department of Physiology and Neurobiology, School of Basic Medical Sciences, Zhengzhou University, No.100 Science Road, Gao-Xin District, Henan, 450001, Zhengzhou, China. zhijuwang@zzu.edu.cn.
  • 9 Department of Physiology and Neurobiology, School of Basic Medical Sciences, Zhengzhou University, No.100 Science Road, Gao-Xin District, Henan, 450001, Zhengzhou, China. xingy@zzu.edu.cn.
PMID: 39177734 DOI: 10.1007/s12035-024-04444-6
Abstract

Postoperative pain is a type of pain that occurs in clinical patients after surgery. Among the factors influencing the transition from acute postoperative pain to chronic postoperative pain, chronic stress has received much attention in recent years. Here, we investigated the role of Dopamine Receptor D1/D2 expressing pyramidal neurons in the prelimbic cortex (PrL) in modulating chronic social defeat stress (CSDS)-induced anxiety-like behavior comorbidity with postoperative hyperalgesia in male mice. Our results showed that preoperative CSDS induced anxiety-like behavior and significantly prolonged postoperative pain caused by plantar incision, but did not affect plantar wound recovery and inflammation. Reduced activation of Dopamine Receptor D1 or D2 expressing neurons in the PrL is a remarkable feature of male mice after CSDS, and chronic inhibition of Dopamine Receptor D1 or D2 expressing neurons in the PrL induced anxiety-like behavior and persistent postoperative pain. Further studies found that activation of D1 expressing but not D2 expressing neurons in the PrL ameliorated CSDS-induced anxiety-like behavior and postoperative hyperalgesia. Our results suggest that Dopamine Receptor D1 expressing neurons in the PrL play a crucial role in CSDS-induced anxiety-like behavior comorbidity with postoperative hyperalgesia in male mice.

Keywords

Anxiety-like behavior; Chronic social defeat stress; Dopamine receptor; Postoperative hyperalgesia; Prelimbic cortex.

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