2. Academic Validation
  3. A dendritic cell-recruiting, antimicrobial blood clot hydrogel for melanoma recurrence prevention and infected wound management

A dendritic cell-recruiting, antimicrobial blood clot hydrogel for melanoma recurrence prevention and infected wound management

  • Biomaterials. 2025 Feb:313:122776. doi: 10.1016/j.biomaterials.2024.122776.
Wen-Shang Liu 1,  Zheng-Mao Lu 2,  Xiao-Hui Pu 3,  Xin-Ying Li 4,  Hui-Qi Zhang 1,  Zhuan-Zhuan Zhang 5,  Xin-Yi Zhang 5,  Te Shi 6,  Xiang-He Jiang 7,  Jing-Sheng Zhou 7,  Xuan Zhou 3,  Zhong-Yuan Xin 8,  Mei-Gui Li 3,  Jing Yuan 9,  Cui-Min Chen 10,  Xiao-Wei Zhang 11,  Jie Gao 12,  Meng Li 13
Affiliations

Affiliations

  • 1 Department of Dermatology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, People's Republic of China; School of Pharmacy, Henan University, Kaifeng, 475004, People's Republic of China.
  • 2 Department of Gastrointestinal Surgery, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, People's Republic of China.
  • 3 School of Pharmacy, Henan University, Kaifeng, 475004, People's Republic of China.
  • 4 Department of Laboratory & Diagnosis, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, People's Republic of China.
  • 5 Institute of Translational Medicine, Shanghai University, Shanghai, 200444, People's Republic of China.
  • 6 Department of Gastroenterology, People's Liberation Army of China Naval Medical Center, Shanghai, 200052, People's Republic of China.
  • 7 College of Life Science, Mudanjiang Medical University, Mudanjiang, 157011, People's Republic of China.
  • 8 School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, People's Republic of China.
  • 9 Department of Pediatrics, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, People's Republic of China.
  • 10 Changhai Clinical Research Unit, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, People's Republic of China.
  • 11 Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, People's Republic of China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, People's Republic of China. Electronic address: dongfangzhizizhxw@aliyun.com.
  • 12 Changhai Clinical Research Unit, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, People's Republic of China. Electronic address: gaojiehighclea@smmu.edu.cn.
  • 13 Department of Dermatology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, People's Republic of China. Electronic address: lemonlives_dr@163.com.
PMID: 39236629 DOI: 10.1016/j.biomaterials.2024.122776
Abstract

Surgical resection, the mainstay for melanoma treatment, faces challenges due to high tumor recurrence rates and complex postoperative wound healing. Chronic inflammation from residual disease and the risk of secondary infections impede healing. We introduce an innovative, injectable hydrogel system that integrates a multifaceted therapeutic approach. The hydrogel, crosslinked by calcium ions with sodium alginate, encapsulates a blood clot rich in dendritic cells (DCs) chemoattractants and melanoma cell-derived nanovesicles (NVs), functioning as a potent immunostimulant. This in situ recruitment strategy overcomes the limitations of subcutaneous tumor vaccine injections and more effectively achieves antitumor immunity. Additionally, the hydrogel incorporates Chlorella extracts, enhancing its antimicrobial properties to prevent wound infections and promote healing. One of the key findings of our research is the dual functionality of Chlorella extracts; they not only expedite the healing process of infected wounds but also increase the hydrogel's ability to stimulate an antitumor immune response. Given the patient-specific nature of the blood clot and NVs, our hydrogel system offers customizable solutions for individual postoperative requirements. This personalized approach is highlighted by our study, which demonstrates the synergistic impact of the composite hydrogel on preventing melanoma recurrence and hastening wound healing, potentially transforming postsurgical melanoma management.

Keywords

Blood clot hydrogel; Chlorella extract; Tumor recurrence; Tumor vaccine; Wound healing.

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