2. Academic Validation
  3. A mucoadhesive-to-penetrating nanomotors-in-hydrogel system for urothelium-oriented intravesical drug delivery

A mucoadhesive-to-penetrating nanomotors-in-hydrogel system for urothelium-oriented intravesical drug delivery

  • J Nanobiotechnology. 2024 Sep 14;22(1):560. doi: 10.1186/s12951-024-02816-7.
Bin Zheng # 1 2,  Haibao Zhang # 3,  Jinxue Wang 4,  Xiaowen Qin 1,  Wentao Xu 5,  Heng Wang 1,  Zhenghong Liu 1,  Yang Liu 1,  Yixuan Mou 1,  Wing-Fu Lai 6,  Youqing Shen 7,  Dahong Zhang 8,  Pu Zhang 9
Affiliations

Affiliations

  • 1 Urology & Nephrology Center, Department of Urology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China.
  • 2 Department of Urology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, 510630, China.
  • 3 Oncology Research Lab, Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an Jiaotong University, Xi'an, People's Republic of China.
  • 4 Center for Rehabilitation Medicine, Department of Neuroelectrophysiology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China.
  • 5 Cancer Center, Department of Interventional Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China.
  • 6 School of Food Science and Nutrition, University of Leeds, Leeds, LS2 9JT, UK.
  • 7 Center for Bionanoengineering and Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, Zhejiang, 310014, China. shenyq@zju.edu.cn.
  • 8 Urology & Nephrology Center, Department of Urology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China. zppurology@163.com.
  • 9 Urology & Nephrology Center, Department of Urology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China. zhangpuxjtuer@163.com.
  • # Contributed equally.
PMID: 39272197 DOI: 10.1186/s12951-024-02816-7
Abstract

Intravesical therapy (IT) is widely used to tackle various urological diseases. However, its clinical efficacy is decreased by the impermeability of various barriers presented on the bladder luminal surface, including the urinary mucus layer and the densely packed tissue barrier. In this study, we report a mucoadhesive-to-penetrating nanomotors-in-hydrogel system for urothelium-oriented intravesical Drug Delivery. Upon intravesical instillation, its poloxamer 407 (PLX) hydrogel gelated and adhered to the urothelium to prolong its intravesical retention. The urea afterwards diffused into the hydrogel, thus generating a concentration gradient. Urease-powered membrane nanomotors (UMN) without asymmetric surface engineering could catalyze the urea and migrate down this concentration gradient to deeply and unidirectionally penetrate the urothelial barrier. Moreover, the intravesical hybrid system-delivered gemcitabine could effectively inhibit the bladder tumor growth without inducing any side effect. Therefore, our mucoadhesive-to-penetrating nanomotors-in-hydrogel system could serve as an alternative to IT to meet the clinical need for more efficacious therapeutics for urological diseases.

Keywords

Intravesical therapy; Mucoadhesive; Mucus-penetrating; Nanomotors.

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