1. Academic Validation
  2. Tumor-Intrinsic Kinome Landscape of Pancreatic Cancer Reveals New Therapeutic Approaches

Tumor-Intrinsic Kinome Landscape of Pancreatic Cancer Reveals New Therapeutic Approaches

  • Cancer Discov. 2025 Feb 7;15(2):346-362. doi: 10.1158/2159-8290.CD-23-1480.
Yi Xu # 1 2 Xianlu L Peng # 1 2 Michael P East 1 Ian C McCabe 2 3 Grace C Stroman 1 2 Madison R Jenner 1 2 Priscilla S Chan 2 Ashley B Morrison 2 Emily C Shen 2 Silvia G Hererra 2 Chinmaya U Joisa 4 Naim U Rashid 2 5 Alina C Iuga 2 6 Shawn M Gomez 1 4 Lisa Miller-Phillips 7 8 Stefan Boeck 7 9 Volker Heinemann 7 9 Michael Haas 7 9 Steffen Ormanns 9 10 Gary L Johnson 1 2 Jen Jen Yeh 1 2 11
Affiliations

Affiliations

  • 1 Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
  • 2 Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
  • 3 Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
  • 4 Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, North Carolina.
  • 5 Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
  • 6 Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
  • 7 Department of Internal Medicine III and Comprehensive Cancer Center, Klinikum Grosshadern, Ludwig-Maximilians-University of Munich, Munich, Germany.
  • 8 Division of Hematology and Oncology, Department of Medicine and Helen Diller Family Comprehensive Cancer Center, UCSF, San Francisco, California.
  • 9 German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany.
  • 10 Institute of Pathology, Faculty of Medicine, Ludwig-Maximilians-University, Munich, Germany.
  • 11 Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
  • # Contributed equally.
Abstract

We provide a comprehensive tumor-intrinsic kinome landscape that provides a roadmap for the use of kinase inhibitors in PDAC treatment approaches.

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