2. Academic Validation
  3. Low-dose exposure to microplastics retards meiotic maturation via HDAC3 insufficiency

Low-dose exposure to microplastics retards meiotic maturation via HDAC3 insufficiency

  • Sci China Life Sci. 2025 Feb 13. doi: 10.1007/s11427-024-2763-6.
Qi Zhao # 1 2,  Ming Zong # 1,  Entong Song # 1,  Hongye Linghu # 1,  Xuanwen Li # 1,  Baicui Wang 1,  Songling Xiao 1,  Wanchun Guan 1,  Jianzhong Su 3 4,  Jiaming Zhang 5 6,  Jingzhang Ji 7,  Qingran Kong 8
Affiliations

Affiliations

  • 1 Zhejiang Provincial Key Laboratory of Medical Genetics, Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, 325035, China.
  • 2 Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou, 325000, China.
  • 3 Zhejiang Provincial Key Laboratory of Medical Genetics, Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, 325035, China. sujz@wmu.edu.cn.
  • 4 Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou, 325000, China. sujz@wmu.edu.cn.
  • 5 Zhejiang Provincial Key Laboratory of Medical Genetics, Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, 325035, China. jmzhang1225@163.com.
  • 6 Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou, 325000, China. jmzhang1225@163.com.
  • 7 Zhejiang Provincial Key Laboratory of Medical Genetics, Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, 325035, China. jjz@wmu.edu.cn.
  • 8 Zhejiang Provincial Key Laboratory of Medical Genetics, Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, 325035, China. kqr721726@163.com.
  • # Contributed equally.
PMID: 39976862 DOI: 10.1007/s11427-024-2763-6
Abstract

Microplastics (MPs) are considered one of the main causes of male and female infertility. However, the reproductive toxicity and its related mechanisms are currently understood primarily through animal models with acute exposure to MPs. In this study, we demonstrate that low-dose exposure to polystyrene microplastics (PSMPs) leads to severely abnormal reproduction in females, manifested by oocyte meiotic maturation defect. Mechanistically, PSMPs exposure induce the overactivation of cell metabolism pathways, insufficient HDACs, and H4K16 hyperacetylation in oocytes both in vivo and in vitro. When an HDAC3 Inhibitor is added, the oocyte maturation defect, overactivation of cell metabolism pathways, and H4K16 hyperacetylation are recapitulated. Conversely, the overexpression of HDAC3 can rescue the defects in meiotic maturation induced by PSMPs. Our observations suggest a direct link between the maturation defects caused by PSMPs and HDAC3 insufficiency. Thus, we propose potential treatments to address the meiotic maturation defect of oocytes in women highly exposed to MPs by activating or supplying HDAC3.

Keywords

H4K16ac; HDACs; cell metabolism; meiotic maturation; polystyrene microplastics.

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