2. Academic Validation
  3. Pharmacological evidence of the stimulation of central alpha-adrenergic receptors

Pharmacological evidence of the stimulation of central alpha-adrenergic receptors

  • Prog Neuropsychopharmacol Biol Psychiatry. 1983;7(2-3):183-6. doi: 10.1016/0278-5846(83)90105-7.
P Simon,  R Chermat,  A J Puech
PMID: 6310690 DOI: 10.1016/0278-5846(83)90105-7
Abstract

We studied the interactions between CRL 40028 (benzhydryl sulfinyl) acetohydroxamic acid) and the alpha 1 blocker prazosin, in mouse. CRL 40028 antagonizes prazosin-induced hypothermia and hypomotility; prazosin antagonizes the anticonvulsant effect of CRL 40028 in the quaking mouse.

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