2. Academic Validation
  3. Biological activity of some coumarins from Sri Lankan Rutaceae

Biological activity of some coumarins from Sri Lankan Rutaceae

  • J Nat Prod. 1994 Apr;57(4):518-20. doi: 10.1021/np50106a013.
A A Gunatilaka 1,  D G Kingston,  E M Wijeratne,  B M Bandara,  G A Hofmann,  R K Johnson
Affiliations

Affiliation

  • 1 Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg 24061-0212.
PMID: 8021652 DOI: 10.1021/np50106a013
Abstract

Twelve Coumarins isolated from Plants of the Rutaceae collected in Sri Lanka have been subjected to a mechanism-based Anticancer bioassay employing DNA repair-deficient and repair-proficient yeasts. Of these, seselin [10] and xanthyletin [11] were found to be active. Seselin also exhibited moderate cytotoxicity.

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