2. Academic Validation
  3. A lymphotoxin-beta-specific receptor

A lymphotoxin-beta-specific receptor

  • Science. 1994 Apr 29;264(5159):707-10. doi: 10.1126/science.8171323.
P D Crowe 1,  T L VanArsdale,  B N Walter,  C F Ware,  C Hession,  B Ehrenfels,  J L Browning,  W S Din,  R G Goodwin,  C A Smith
Affiliations

Affiliation

  • 1 Division of Biomedical Sciences, University of California, Riverside 92521.
PMID: 8171323 DOI: 10.1126/science.8171323
Abstract

Tumor necrosis factor (TNF) and lymphotoxin-alpha (LT-alpha) are members of a family of secreted and cell surface cytokines that participate in the regulation of immune and inflammatory responses. The cell surface form of LT-alpha is assembled during biosynthesis as a heteromeric complex with lymphotoxin-beta (LT-beta), a type II transmembrane protein that is another member of the TNF ligand family. Secreted LT-alpha is a homotrimer that binds to distinct TNF receptors of 60 and 80 kilodaltons; however, these receptors do not recognize the major cell surface LT-alpha-LT-beta complex. A receptor specific for human LT-beta was identified, which suggests that cell surface LT may have functions that are distinct from those of secreted LT-alpha.

Figures