2. Academic Validation
  3. Prevention of sudden cardiac death by the atypical neuroleptic acepromazine following status epilepticus in rats

Prevention of sudden cardiac death by the atypical neuroleptic acepromazine following status epilepticus in rats

  • Life Sci. 1994;54(24):PL457-62. doi: 10.1016/0024-3205(94)90156-2.
T Harrigan 1,  Y R Bureau,  M A Persinger,  G H Parker
Affiliations

Affiliation

  • 1 Behavioral Neuroscience Laboratory, Laurentian University, Sudbury, Ontario.
PMID: 8196501 DOI: 10.1016/0024-3205(94)90156-2
Abstract

Normal male rats in which status epilepticus has been induced by injecting 30 mg/kg of pilocarpine after a single systemic administration of lithium (sufficient to produce blood levels of 0.2 mEq/L) invariably die within 24 hr. Real-time monitoring indicated sudden cardiac death; it was preceded by progressive intensification of arrhythmia. A single systemic injection (25 mg/kg) of the atypical phenothiazine acepromazine prevented the mortality and virtually eliminated the cardiac instability.

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