2. Academic Validation
  3. Nigranoic acid, a triterpenoid from Schisandra sphaerandra that inhibits HIV-1 reverse transcriptase

Nigranoic acid, a triterpenoid from Schisandra sphaerandra that inhibits HIV-1 reverse transcriptase

  • J Nat Prod. 1996 May;59(5):525-7. doi: 10.1021/np960149h.
H D Sun 1,  S X Qiu,  L Z Lin,  Z Y Wang,  Z W Lin,  T Pengsuparp,  J M Pezzuto,  H H Fong,  G A Cordell,  N R Farnsworth
Affiliations

Affiliation

  • 1 Laboratory of Phytochemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan, People's Republic of China.
PMID: 8778243 DOI: 10.1021/np960149h
Abstract

An A ring-secocycloartene triterpenoid, nigranoic acid (3,4-secocycloarta-4(28),24-(Z)-diene-3,-26-dioic acid, (1) was isolated from the stems of Schisandra sphaerandra, a Chinese traditional medicinal plant. Its structure elucidation and unambiguous NMR spectral assignment were achieved by the combination of 1D- and 2D-NMR techniques with the aid of computer modeling. Nigranoic acid showed activity in several anti-HIV Reverse Transcriptase and polymerase assays.

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