1. Academic Validation
  2. Phytogrowth-inhibitory and antifungal constituents of Helianthella quinquenervis

Phytogrowth-inhibitory and antifungal constituents of Helianthella quinquenervis

  • J Nat Prod. 1996 Mar;59(3):323-6. doi: 10.1021/np960199m.
P Castañeda 1 L Gómez R Mata B Lotina-Hennsen A L Anaya R Bye
Affiliations

Affiliation

  • 1 Departamento de Farmacia, Instituto de Química, Mexico.
Abstract

Investigation on the roots of Helianthella quinquenervis (Hook.) A. Gray (Asteraceae), led to the isolation of one new benzofuran (6-methoxy-tremetone (1)) and a new prenylacetophenone (4-beta-D-(glucopyranosyloxy)-3-[3-methoxy-trans-isopenten-1 -yl] acetophenone (3)). In addition, 6-hydroxy-3-methoxytremetone (2), encecalin (6), euparin (5), demethylencecalin (4), and angelic acid were obtained. Structural assignments of the isolated compounds were based on spectroscopic and spectrometric analysis. Natural Products 1-4 showed marginal cytotoxicity against three human tumor cell lines [MCF-7, A-549, and HT-29]. Compounds 4 and 6 inhibited the radicle growth of Amaranthus hypochondriacus and Echinochloa crusgalli. Furthermore, substances 4-6 exhibited Antifungal activity against Trichophyton mentagrophytes.

Figures