2. Academic Validation
  3. The identification of DL-threo dihydrosphingosine and sphingosine as novel inhibitors of extracellular signal-regulated kinase signalling in airway smooth muscle

The identification of DL-threo dihydrosphingosine and sphingosine as novel inhibitors of extracellular signal-regulated kinase signalling in airway smooth muscle

  • Br J Pharmacol. 1996 Sep;119(2):185-6. doi: 10.1111/j.1476-5381.1996.tb15967.x.
D Tolan 1,  A M Conway,  L Steele,  S Pyne,  N J Pyne
Affiliations

Affiliation

  • 1 Department of Physiology and Pharmacology, University of Strathclyde, Glasgow.
PMID: 8886394 DOI: 10.1111/j.1476-5381.1996.tb15967.x
Abstract

We present entirely novel evidence that DL-threo dihydrosphingosine and sphingosine are inhibitors of the extracellular signal-regulated kinase (ERK) signalling cassette in mammalian cells. We show that DL-threo dihydrosphingosine is effective against both growth factor- and G-protein-dependent activation of ERK. We conclude that DL-threo dihydrosphingosine may represent an important pharmacological cell-permeable agent that may be usefully employed to block smooth muscle cell proliferation.

Figures
Products