The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

Nature. 1996 Nov 14;384(6605):129-34. doi: 10.1038/384129a0.

D M Stone ¹, M Hynes, M Armanini, T A Swanson, Q Gu, R L Johnson, M P Scott, D Pennica, A Goddard, H Phillips, M Noll, J E Hooper, F de Sauvage, A Rosenthal

Affiliations

Affiliation

1 Department of Neuroscience, Genentech, Inc., South San Francisco, California 94080, USA.

PMID: 8906787 DOI: 10.1038/384129a0

Abstract

The protein Sonic Hedgehog (Shh) controls patterning and growth during vertebrate development. Here we demonstrate that it binds Patched (vPtc), which has been identified as a tumour-suppressor protein in basal cell carcinoma, with high affinity. We show that Ptc can form a physical complex with a newly cloned vertebrate homologue of the Drosophila protein Smoothened (vSmo), and that vSmo is coexpressed with vPtc in many tissues but does not bind Shh directly. These findings, combined with available genetic evidence from Drosophila, support the hypothesis that Ptc is a receptor for Shh, and that vSmo could be a signalling component that is linked to Ptc.

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