2. Academic Validation
  3. The therapeutic effect of a combination of cofpropamine, a caffeine derivative, and cyclophosphamide on the development of adjuvant arthritis of rats and collagen arthritis of mice

The therapeutic effect of a combination of cofpropamine, a caffeine derivative, and cyclophosphamide on the development of adjuvant arthritis of rats and collagen arthritis of mice

  • Gen Pharmacol. 1996 Oct;27(7):1215-8. doi: 10.1016/s0306-3623(96)00069-9.
H Kröger 1,  J Klosa,  R Grätz,  A Dietrich,  W Ehrlich,  A Wild
Affiliations

Affiliation

  • 1 Deutsches Rheumaforschungszentrum Berlin, Germany.
PMID: 8981070 DOI: 10.1016/s0306-3623(96)00069-9
Abstract

1. Cofpropamine (Cofa), a caffeine derivative that inhibits polyadenoribosylation, enhances the therapeutic effect of cyclophosphamide (CPA) in two animal models of arthritis. 2. The development of Adjuvant arthritis of rats is reduced by treatment with 2 x 50 mg/kg IP CPA and 2 x 50 mg/kg IP Cofa. 3. The development of collagen arthritis in mice is prevented by treatment with 12.5 mg/kg IP CPA and 150 mg/kg IP Cofa three times per week.

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