2. Academic Validation
  3. Decursinol angelate: a cytotoxic and protein kinase C activating agent from the root of Angelica gigas

Decursinol angelate: a cytotoxic and protein kinase C activating agent from the root of Angelica gigas

  • Planta Med. 1997 Aug;63(4):360-1. doi: 10.1055/s-2006-957701.
K S Ahn,  W S Sim,  I K Lee,  Y B Seu,  I H Kim
PMID: 9270380 DOI: 10.1055/s-2006-957701
Abstract

A cytotoxic compound was purified from the root of Angelica gigas Nakai by normal phase HPLC. As a result of the structure analysis by mass, IR, 1H-NMR, and 13C-NMR spectrometry, the compound was identified as decursinol angelate, a structural isomer of decursin, and characterized originally from Sesei grandivittatum. Decursinol angelate showed in vitro cytotoxicity and protein kinase C activating activities like decursin.

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