2. Academic Validation
  3. Bovine herpesvirus 4 BORFE2 protein inhibits Fas- and tumor necrosis factor receptor 1-induced apoptosis and contains death effector domains shared with other gamma-2 herpesviruses

Bovine herpesvirus 4 BORFE2 protein inhibits Fas- and tumor necrosis factor receptor 1-induced apoptosis and contains death effector domains shared with other gamma-2 herpesviruses

  • J Virol. 1997 Nov;71(11):8928-32. doi: 10.1128/JVI.71.11.8928-8932.1997.
G H Wang 1,  J Bertin,  Y Wang,  D A Martin,  J Wang,  K J Tomaselli,  R C Armstrong,  J I Cohen
Affiliations

Affiliation

  • 1 Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA. gwang@atlas.niaid.nih.gov
PMID: 9343261 DOI: 10.1128/JVI.71.11.8928-8932.1997
Abstract

Fas- and tumor necrosis factor receptor 1 (TNFR1)-induced Apoptosis is mediated by the interaction of FADD with Caspase-8. Here, we report that the bovine herpesvirus 4 (BHV4) BORFE2 gene encodes a protein that inhibits Fas- and TNFR1-induced Apoptosis and contains death effector domains (DEDs). Using the yeast two-hybrid system, we found that the BORFE2 protein interacts with the prodomain of Caspase-8. Furthermore, we show that BHV4 BORFE2 is a member of a family of DED-containing proteins that includes Other gamma-2 herpesviruses, such as Kaposi's sarcoma-associated herpesvirus and herpesvirus saimiri.

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