2. Academic Validation
  3. Epoxyquinomicins A, B, C and D, new antibiotics from Amycolatopsis. I. Taxonomy, fermentation, isolation and antimicrobial activities

Epoxyquinomicins A, B, C and D, new antibiotics from Amycolatopsis. I. Taxonomy, fermentation, isolation and antimicrobial activities

  • J Antibiot (Tokyo). 1997 Nov;50(11):900-5. doi: 10.7164/antibiotics.50.900.
N Matsumoto 1,  T Tsuchida,  M Umekita,  N Kinoshita,  H Iinuma,  T Sawa,  M Hamada,  T Takeuchi
Affiliations

Affiliation

  • 1 Institute of Microbial Chemistry, Tokyo, Japan.
PMID: 9592560 DOI: 10.7164/antibiotics.50.900
Abstract

A new structural class of the Antibiotic, epoxyquinomicins A, B, C and D were isolated from the culture broth of the strain MK299-95F4, which was related to Amycolatopsis sulphurea. Antimicrobial activity of epoxyquinomicins A and B were weak against Gram-positive bacteria, and epoxyquinomicins C and D showed almost no antimicrobial activity and no cytotoxicity. All these Antibiotics showed improvement of collagen induced arthritis in vivo.

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