2. Academic Validation
  3. Intestinal lactase-phlorizin hydrolase (LPH): the two catalytic sites; the role of the pancreas in pro-LPH maturation

Intestinal lactase-phlorizin hydrolase (LPH): the two catalytic sites; the role of the pancreas in pro-LPH maturation

  • FEBS Lett. 1998 Sep 18;435(2-3):225-8. doi: 10.1016/s0014-5793(98)01076-x.
L Zecca 1,  J E Mesonero,  A Stutz,  J C Poirée,  J Giudicelli,  R Cursio,  S M Gloor,  G Semenza
Affiliations

Affiliation

  • 1 Department of Biochemistry, Swiss Federal Institute of Technology, ETH Zentrum, Zurich.
PMID: 9762914 DOI: 10.1016/s0014-5793(98)01076-x
Abstract

Brush border lactase-phlorizin hydrolase carries two catalytic sites. In the human Enzyme lactase comprises Glu-1749, phlorizin hydrolase Glu-1273. The proteolytic processing of pro-lactase-phlorizin hydrolase by (rat) enterocytes stops two amino acid residues short of the N-terminus of 'mature' final, brush border lactase-phlorizin hydrolase. Only these two amino acid residues are removed by luminal pancreatic protease(s), probably trypsin.

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