Promising new agents for treatment of patients with colorectal cancer

Colorectal Cancer continues to be a major problem. There are a number of new agents with promising clinical activity, including the multitargeted Antifolate LY 231514 and the thymidylate synthesis inhibitor capecitabine. In addition, other agents have shown promising preclinical activity against the disease: 6-hydroxymethylacylfulvene (HMAF; MGI 114), LY 295501, bizelesin (U-7779; NSC615291), and ONYX-015. Finally, several agents may prevent colorectal Cancer through prevention of the formation of colorectal polyps (eg, cyclooxygenase inhibitors).