2. Academic Validation
  3. Peptidyl beta-homo-aspartals: specific inhibitors of interleukin-1 beta converting enzyme and its homologues (caspases)

Peptidyl beta-homo-aspartals: specific inhibitors of interleukin-1 beta converting enzyme and its homologues (caspases)

  • Bioorg Med Chem Lett. 1998 Jun 16;8(12):1477-82. doi: 10.1016/s0960-894x(98)00244-3.
S Bajusz 1,  I Fauszt,  K Németh,  E Barabás,  A Juhász,  M Patthy
Affiliations

Affiliation

  • 1 Institute for Drug Research, Budapest, Hungary. h13770baj@ella.hu
PMID: 9873373 DOI: 10.1016/s0960-894x(98)00244-3
Abstract

Inhibition of interleukin-1 beta converting Enzyme (ICE), apopain, papain, Thrombin and trypsin with substrate like peptidyl L- and D-alpha-aldehydes and their L-beta-homo-aldehyde analogues was investigated. The L-beta-homo-aspartals appear to be specific inhibitors for ICE and its homologues; the other Enzymes were not inhibited with such L-beta-homo aldehydes. Papain shows tolerance for D-residues at P1 depending on their chiral stability.

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