2. Academic Validation
  3. Novel anti-HIV lancilactone C and related triterpenes from Kadsura lancilimba

Novel anti-HIV lancilactone C and related triterpenes from Kadsura lancilimba

  • J Nat Prod. 1999 Jan;62(1):94-7. doi: 10.1021/np980291d.
D F Chen 1,  S X Zhang,  H K Wang,  S Y Zhang,  Q Z Sun,  L M Cosentino,  K H Lee
Affiliations

Affiliation

  • 1 Department of Pharmacognosy, School of Pharmacy, Shanghai Medical University, Shanghai 200032, People's Republic of China. dfchen@shmu.edu.cn
PMID: 9917290 DOI: 10.1021/np980291d
Abstract

Three new triterpene lactones, lancilactones A (1), B (2), and C (3), together with the known kadsulactone A (4), were isolated from the stems and roots of Kadsura lancilimba. Their structures and stereochemistries were determined primarily from mass and NMR spectral data. Compound 3 inhibited HIV replication with an EC50 value of 1.4 microg/mL and a therapeutic index of greater than 71.4.

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