2. PROTAC Apoptosis
  3. PROTACs MDM-2/p53
  4. MD-265

MD-265 is a PROTAC degrader that can break down MDM2, leading to activation of p53 in cancer cells carrying wild-type p53. MD-265 achieves complete tumor regression and improves long-term survival of mice with leukemia. (Pink: MI-1063 (HY-133754); Black: linker; Blue: Lenalidomide (HY-A0003).

For research use only. We do not sell to patients.

MD-265 Chemical Structure

MD-265 Chemical Structure

CAS No. : 2415160-21-1

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MD-265 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

MD-265 is a PROTAC degrader that can break down MDM2, leading to activation of p53 in cancer cells carrying wild-type p53. MD-265 achieves complete tumor regression and improves long-term survival of mice with leukemia. (Pink: MI-1063 (HY-133754); Black: linker; Blue: Lenalidomide (HY-A0003)[1].

Molecular Weight

921.88

Formula

C50H51Cl2FN6O6
CAS No.
SMILES

O=C([C@H]1CC[C@@H](CC1)NC([C@@H]2NC3(CCCCC3)[C@]4(C5=CC=C(C=C5NC4=O)Cl)[C@H]2C6=CC=CC(Cl)=C6F)=O)N7CCC(C#CC8=C(C(C9=O)=CC=C8)CN9C(C(N%10)=O)CCC%10=O)CC7
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
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References
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MD-265 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MD-2652415160-21-1MD265MD 265PROTACsMDM-2/p53PROTACMDM2p53tumorleukemiaInhibitorinhibitorinhibit

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