MD6a

Cat. No.: HY-162363: FAQs
Data Sheet Handling Instructions

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MD6a is a melatonin derivative with inhibitroy activity towards PARP-1, which maintains proteins hemostasis and improves mitochondrial function through TOR/HSF-1 signaling. MD6a a neuroprotective effect.

For research use only. We do not sell to patients.

MD6a Chemical Structure

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•Related Small Molecules:

•Related Proteins:

View All PARP Isoform Specific Products:

View All Isoforms

PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

MD6a (10 μM) inhibits PARP-1 to downregulate let-363/hsf-1 signaling by targeting hsp-4 and hsp-6, thus reducing α-syn aggregation and enhances mitochondrial function in C. elegans^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[1]

Cell Line:	wildtype N2, NL5901, parp-1 RNAi
Concentration:	10 μM
Incubation Time:	48 h
Result:	Reduced levels of parp-1 mRNA, parp-1 dependent α-syn aggregation and mitochondrial ROS levels.

Molecular Weight

334.41

Formula

C₂₁H₂₂N₂O₂

SMILES

COC1=CC(/C=C/C2=CC=CC=C2)=C(NC=C3CCNC(C)=O)C3=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ma QW, et al., Melatonin derivative 6a as a PARP-1 inhibitor for the treatment of Parkinson's disease. Front Pharmacol. 2024 Feb 27;15:1363212. [Content Brief]

MD6a Related Classifications

Neurological Disease

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MD6aPARPpoly ADP ribose polymeraseneurologicalantioxidantwild type N2NL590BZ555DAdopaminergic neuronα-synParkinson's diseaseInhibitorinhibitorinhibit

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