2. Cell Cycle/DNA Damage Epigenetics
  3. PARP
  4. MD6a

MD6a is a melatonin derivative with inhibitroy activity towards PARP-1, which maintains proteins hemostasis and improves mitochondrial function through TOR/HSF-1 signaling. MD6a a neuroprotective effect.

For research use only. We do not sell to patients.

MD6a Chemical Structure

MD6a Chemical Structure

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MD6a Related Antibodies

Top Publications Citing Use of Products

View All PARP Isoform Specific Products:

View All Isoforms
PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

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Description

MD6a is a melatonin derivative with inhibitroy activity towards PARP-1, which maintains proteins hemostasis and improves mitochondrial function through TOR/HSF-1 signaling. MD6a a neuroprotective effect[1].

In Vitro

MD6a (10 μM) inhibits PARP-1 to downregulate let-363/hsf-1 signaling by targeting hsp-4 and hsp-6, thus reducing α-syn aggregation and enhances mitochondrial function in C. elegans[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MD6a Related Antibodies

Real Time qPCR[1]

Cell Line: wildtype N2, NL5901, parp-1 RNAi
Concentration: 10 μM
Incubation Time: 48 h
Result: Reduced levels of parp-1 mRNA, parp-1 dependent α-syn aggregation and mitochondrial ROS levels.
Molecular Weight

334.41

Formula

C21H22N2O2
SMILES

COC1=CC(/C=C/C2=CC=CC=C2)=C(NC=C3CCNC(C)=O)C3=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MD6a Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MD6aPARPpoly ADP ribose polymeraseneurologicalantioxidantwild type N2NL590BZ555DAdopaminergic neuronα-synParkinson's diseaseInhibitorinhibitorinhibit

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