1. GPCR/G Protein
  2. Prostaglandin Receptor
  3. MF-592

MF-592 is an inhibitor of PGE2 (IC50=3 nM) and exhibits good oral PK properties in rats and dogs.

For research use only. We do not sell to patients.

MF-592 Chemical Structure

MF-592 Chemical Structure

CAS No. : 1064195-48-7

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Description

MF-592 is an inhibitor of PGE2 (IC50=3 nM) and exhibits good oral PK properties in rats and dogs.

Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
14 nM
Compound: 2f, MF-592
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serum
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serum
[PMID: 21215624]
HEK293 IC50
3 nM
Compound: 2; MF-592
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assay
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assay
[PMID: 26764191]
HEK293 IC50
3 nM
Compound: 2f, MF-592
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting
[PMID: 21215624]
Molecular Weight

682.61

Formula

C34H33Cl2N3O6S

CAS No.
SMILES

O=S(C1=C(C=CC=C1Cl)Cl)(NC(NC2(CC2)CC3=CC=C(C(C)=C3)N(C4=O)CC5=C4C(OCC)=C6C=CC=CC6=C5OCC)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
MF-592
Cat. No.:
HY-118370
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