2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. MFZ 10-7 hydrochloride

MFZ 10-7 hydrochloride is a highly potent and selective mGluR5 NAM (negative allosteric modulator), with a Ki of 0.67 nM for rat mGluR5. MFZ 10-7 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

MFZ 10-7 hydrochloride Chemical Structure

MFZ 10-7 hydrochloride Chemical Structure

CAS No. : 1779796-36-9

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Other Forms of MFZ 10-7 hydrochloride:

MFZ 10-7 hydrochloride Related Antibodies

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Description

MFZ 10-7 hydrochloride is a highly potent and selective mGluR5 NAM (negative allosteric modulator), with a Ki of 0.67 nM for rat mGluR5[1]. MFZ 10-7 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target[1]

rat mGluR5

0.67 nM (Ki)

In Vitro

MFZ 10-7 hydrochloride has approximately 1150- and 3000-fold lower affinity for MAO-B (monoamine oxidase-B enzyme) and TXA2 (thromboxane A2 receptor), respectively, compared to mGluR5[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MFZ 10-7 hydrochloride Related Antibodies
In Vivo

MFZ 10-7 hydrochloride can lower oral sucrose self-administration rate but has no effect on total sucrose intake[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

272.70

Formula

C15H10ClFN2
CAS No.
SMILES

N#CC1=CC(C#CC2=NC(C)=CC=C2)=CC(F)=C1.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MFZ 10-7 hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MFZ 10-71779796-36-9mGluRMetabotropic glutamate receptorsInhibitorinhibitorinhibit

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