mgc(3Me)FDA

Cat. No.: HY-D2300: FAQs
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mgc(3Me)FDA is fluorescein diacetate (FDA) modified with a cell-permeable myrGC^3Me motif. mgc(3Me)FDA can enter cells and be converted into fluorescently active mgc(3Me)FL (HY-D2301) within the cells. mgc(3Me)FDA is subcellularly localized in the Golgi apparatus and is a visualized Golgi probe.

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mgc(3Me)FDA Chemical Structure

CAS No. : 2763442-01-7

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Description

In Vitro

After mgc(3Me)FDA (10 μM; 10 min) treats HeLa cells, it can co-localize with the Golgi apparatus around the nucleus and display green fluorescence^[1].
mgc(3Me)FDA (2.5 μM; 30-270 min ) In HeLa living cells induced by Brefeldin A (HY-16592), dynamic changes in morphology during Golgi cleavage can be visualized^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Immunofluorescence^[1]

Cell Line:	Human epithelial HeLa cells
Concentration:	10 μM
Incubation Time:	10 min
Result:	Occured fluorescence mainly in the perinuclear Golgi region and co-localized with Golgi-tagged fluorescent protein (mCherry-Giantin).

Molecular Weight

1145.36

Formula

C₅₉H₈₀N₆O₁₅S

CAS No.

2763442-01-7

SMILES

O=C1OC2(C3=CC=C(OC(C)=O)C=C3OC4=CC(OC(C)=O)=CC=C42)C5=CC=C(C(NCCCC[C@@H](C(N)=O)NC(COCCOCCN(C)C([C@H](CS)N(C)C(CN(C)C(CCCCCCCCCCCCC)=O)=O)=O)=O)=O)C=C51

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Sawada S, et al. Palmitoylation-Dependent Small-Molecule Fluorescent Probes for Live-Cell Golgi Imaging. ACS Chem Biol. 2023 May 19;18(5):1047-1053. [Content Brief]

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

mgc(3Me)FDA2763442-01-7Fluorescent DyeGolgi apparatuscell permeabilitylive cell dyesconfocal microscopyInhibitorinhibitorinhibit

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