MI-219

Cat. No.: HY-18331: FAQs
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MI-219 is an antagonist for MDM2 with a K_i of 13.3 μM. MI-219 inhibits the MDM2-p53 interaction, inhibits thus the proliferation of FSCCL cells, with an IC₅₀ of 2.5 μM.

For research use only. We do not sell to patients.

MI-219 Chemical Structure

CAS No. : 908027-55-4

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Description

MI-219 is an antagonist for MDM2 with a K_i of 13.3 μM. MI-219 inhibits the MDM2-p53 interaction, inhibits thus the proliferation of FSCCL cells, with an IC₅₀ of 2.5 μM^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	1.1 μM Compound: 7, MI-219	Growth inhibition of human HCT116 cells expressing wild type p53 gene after 4 days by WST8 dye reduction assay Growth inhibition of human HCT116 cells expressing wild type p53 gene after 4 days by WST8 dye reduction assay	[PMID: 19928922]
HCT-116	IC₅₀	24.8 μM Compound: 7, MI-219	Growth inhibition of human HCT116 cells deficient in p53 gene expression after 4 days by WST8 dye reduction assay Growth inhibition of human HCT116 cells deficient in p53 gene expression after 4 days by WST8 dye reduction assay	[PMID: 19928922]
RS4-11	IC₅₀	0.54 μM Compound: 1, MI-219	Cytotoxicity against human RS4:11 cells expressing wild type p53 assessed as growth inhibition by WST-8 assay Cytotoxicity against human RS4:11 cells expressing wild type p53 assessed as growth inhibition by WST-8 assay	[PMID: 23786219]
SAOS-2	IC₅₀	15.4 μM Compound: 7, MI-219	Growth inhibition of human Saos2 cells deficient in p53 gene expression after 4 days by WST8 dye reduction assay Growth inhibition of human Saos2 cells deficient in p53 gene expression after 4 days by WST8 dye reduction assay	[PMID: 19928922]
SJSA-1	IC₅₀	0.7 μM Compound: 7, MI-219	Growth inhibition of human SJSA1 cells expressing wild type p53 gene after 4 days by WST8 dye reduction assay Growth inhibition of human SJSA1 cells expressing wild type p53 gene after 4 days by WST8 dye reduction assay	[PMID: 19928922]
SJSA-1	IC₅₀	0.89 μM Compound: 1, MI-219	Cytotoxicity against human SJSA1 cells expressing wild type p53 assessed as growth inhibition by WST-8 assay Cytotoxicity against human SJSA1 cells expressing wild type p53 assessed as growth inhibition by WST-8 assay	[PMID: 23786219]

Molecular Weight

552.47

Formula

C₂₇H₃₂Cl₂FN₃O₄

CAS No.

908027-55-4

SMILES

O=C([C@H](N[C@@H]1CC(C)(C)C)[C@H](C2=CC=CC(Cl)=C2)[C@]31C(NC4=C3C=C(F)C(Cl)=C4)=O)NCC[C@H](O)CO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Mohammad RM, et al., An MDM2 antagonist (MI-319) restores p53 functions and increases the life span of orally treated follicular lymphoma bearing animals. Mol Cancer. 2009 Dec 3;8:115. [Content Brief]

MI-219 Related Classifications

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MI-219908027-55-4MI219MI 219MDM-2/p53WMDLCL2FSCCLInhibitorinhibitorinhibit

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