2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. Microtubule inhibitor 6

Microtubule inhibitor 6 (compound 17o) is a potent microtubule inhibitor. Microtubule inhibitor 6 shows cytotoxicity with IC50s of 14.0, 6.6, 7.0 nM for NCI-H460, BxPC-3, HT-29 cells, respectively. Microtubule inhibitor 6 efficiently inhibits microtubule polymerization.

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Microtubule inhibitor 6 Chemical Structure

Microtubule inhibitor 6 Chemical Structure

CAS No. : 2416338-64-0

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Microtubule inhibitor 6 Related Antibodies

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Description

Microtubule inhibitor 6 (compound 17o) is a potent microtubule inhibitor. Microtubule inhibitor 6 shows cytotoxicity with IC50s of 14.0, 6.6, 7.0 nM for NCI-H460, BxPC-3, HT-29 cells, respectively. Microtubule inhibitor 6 efficiently inhibits microtubule polymerization[1].

Cellular Effect
Cell Line Type Value Description References
BXPC-3 IC50
6.6 nM
Compound: 17o
Cytotoxicity against human BxPC3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human BxPC3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 32278711]
HT-29 IC50
7 nM
Compound: 17o
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 32278711]
NCI-H460 IC50
14 nM
Compound: 17o
Cytotoxicity against human NCI-H460 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human NCI-H460 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 32278711]
Molecular Weight

434.42

Formula

C24H19FN2O5
CAS No.
SMILES

COCC1=CC=C(O1)/C=C2NC(/C(NC\2=O)=C/C3=CC(OC4=CC=C(C=C4)F)=CC=C3)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
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References
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Microtubule inhibitor 6 Related Classifications

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  • Do most proteins show cross-species activity?

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Keywords:

Microtubule inhibitor 62416338-64-0Microtubule inhibitor6Microtubule inhibitor-6Microtubule/Tubulintubulin polymerizationNCI-H460BxPC-3HT-29cytotoxicityantiproliferative， anticancerInhibitorinhibitorinhibit

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