2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. Microtubule inhibitor 7

Compounds 17O (ic50= 14.0 nm, NCI-H460) and 17p (ic50= 2.9 nm, NCI-H460) and furan groups showed effective cytotoxic activity against various human cancer cell lines at the nanomolar level.

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Microtubule inhibitor 7 Chemical Structure

Microtubule inhibitor 7 Chemical Structure

CAS No. : 2416338-65-1

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Microtubule inhibitor 7 Related Antibodies

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Description

Compounds 17O (ic50= 14.0 nm, NCI-H460) and 17p (ic50= 2.9 nm, NCI-H460) and furan groups showed effective cytotoxic activity against various human cancer cell lines at the nanomolar level.

Cellular Effect
Cell Line Type Value Description References
BXPC-3 IC50
2 nM
Compound: 17p
Cytotoxicity against human BxPC3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human BxPC3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 32278711]
HT-29 IC50
2.2 nM
Compound: 17p
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 32278711]
NCI-H460 IC50
2.9 nM
Compound: 17p
Cytotoxicity against human NCI-H460 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human NCI-H460 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 32278711]
Molecular Weight

446.43

Formula

C25H19FN2O5
CAS No.
SMILES

O=C(C1=CC=CC(/C=C2NC(/C(NC\2=O)=C/C3=CC=C(O3)COC)=O)=C1)C4=CC=C(C=C4)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Microtubule inhibitor 7 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Microtubule inhibitor 72416338-65-1Microtubule inhibitor7Microtubule inhibitor-7Microtubule/TubulinInhibitorinhibitorinhibit

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