(-)-Gallopamil hydrochloride  (Synonyms: (-)-Methoxyverapamil hydrochloride)

(-)-Gallopamil (hydrochloride) exerts a selective modulation of the fast voltage-dependent inactivation. (-)-Gallopamil (hydrochloride) inhibits efficiently Cav1.2 constructs formed by β-subunits (promoting fast voltage-dependent inactivation). (-)-Gallopamil (hydrochloride) also accelerates the voltage-dependent phase of I_Ca decay (as well as the voltage-dependent decay of Ba²⁺ currents). (-)-Gallopamil (hydrochloride) is promising for research of antiarrhythmics^[1][2].

521.09

C₂₈H₄₁ClN₂O₅

36622-39-6

N#C[C@](C(C)C)(CCCN(CCC1=CC=C(OC)C(OC)=C1)C)C2=CC(OC)=C(OC)C(OC)=C2.Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Sokolov S, et al. On the role of Ca(2+)- and voltage-dependent inactivation in Ca(v)1.2 sensitivity for the phenylalkylamine (-)gallopamil. Circ Res. 2001 Oct 12;89(8):700-8.  [Content Brief]

  [2]. Sokolov S, et al. Inactivation determinant in the I-II loop of the Ca2+ channel alpha1-subunit and beta-subunit interaction affect sensitivity for the phenylalkylamine (-)gallopamil. J Physiol. 1999 Sep 1;519 Pt 2(Pt 2):315-22.  [Content Brief]