2. Immunology/Inflammation Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. Glucocorticoid Receptor Mineralocorticoid Receptor
  4. Miricorilant

Miricorilant (CORT 118335) is a dual selective glucocorticoid (GR) modulator/mineralocorticoid (MR) antagonist. Miricorilant can be used for the research of hypothalamic-pituitary-adrenal (HPA) axis related disorders.

For research use only. We do not sell to patients.

Miricorilant Chemical Structure

Miricorilant Chemical Structure

CAS No. : 1400902-13-7

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Miricorilant Related Antibodies

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Description

Miricorilant (CORT 118335) is a dual selective glucocorticoid (GR) modulator/mineralocorticoid (MR) antagonist. Miricorilant can be used for the research of hypothalamic-pituitary-adrenal (HPA) axis related disorders[1].

IC50 & Target

Glucocorticoid/Mineralocorticoid[1]
In Vivo

CORT 118335 (3-30 mg/kg) potently suppresses endocrine responses to two different stressors (restraint and FST) in male rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (≈250 g)[1]
Dosage: 3 mg/kg, 10 mg/kg, 30 mg/kg
Administration: Subcutaneously (s.c.); five days.
Result: 30 mg/kg had lower corticosterone responses relative to 10 mg/kg at 15 and 30 min time points.
Molecular Weight

428.45

Formula

C24H23F3N2O2
CAS No.
SMILES

O=C1NC(C(CC2=CC=CC(C(F)(F)F)=C2)=C(N1)[C@H]3CC[C@@H](CC3)C4=CC=CC=C4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Miricorilant Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Miricorilant1400902-13-7CORT 118335CORT118335CORT-118335Glucocorticoid ReceptorMineralocorticoid Receptorglucocorticoidmineralocorticoidhypothalamicpituitary,adrenalHPAaxisInhibitorinhibitorinhibit

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HY-117965
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