2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. Mitragynine pseudoindoxyl

Mitragynine pseudoindoxyl is a potent MOR agonist. Mitragynine pseudoindoxyl displays reduced hyperlocomotion, inhibition of GI transit and reinforcing properties.

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Mitragynine pseudoindoxyl Chemical Structure

Mitragynine pseudoindoxyl Chemical Structure

CAS No. : 2035457-43-1

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Mitragynine pseudoindoxyl Related Antibodies

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μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

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Description

Mitragynine pseudoindoxyl is a potent MOR agonist. Mitragynine pseudoindoxyl displays reduced hyperlocomotion, inhibition of GI transit and reinforcing properties[1].

Cellular Effect
Cell Line Type Value Description References
CHO EC50
1.7 nM
Compound: 3; Mitragynine Pseudoindoxyl
Agonist activity at mouse mu opioid receptor-1 expressed in CHO cell membranes assessed as [35S]GTPgammaS binding incubated for 60 mins by scintillation spectroscopic analysis
Agonist activity at mouse mu opioid receptor-1 expressed in CHO cell membranes assessed as [35S]GTPgammaS binding incubated for 60 mins by scintillation spectroscopic analysis
[PMID: 27556704]
CHO IC50
31 nM
Compound: 3; Mitragynine Pseudoindoxyl
Antagonist activity at mouse kappa opioid receptor-1 expressed in CHO cell membranes assessed as inhibition of U50,488H-induced [35S]GTPgammaS binding incubated for 60 mins by scintillation spectroscopic analysis
Antagonist activity at mouse kappa opioid receptor-1 expressed in CHO cell membranes assessed as inhibition of U50,488H-induced [35S]GTPgammaS binding incubated for 60 mins by scintillation spectroscopic analysis
[PMID: 27556704]
CHO IC50
34 nM
Compound: 3; Mitragynine Pseudoindoxyl
Inhibition of DAMGO-induced beta-arrestin-2 recruitment at mu opioid receptor-1 (unknown origin) expressed in CHO cells preincubated for 30 mins followed by DAMGO addition measured after 90 mins by beta-galactosidase complementation assay
Inhibition of DAMGO-induced beta-arrestin-2 recruitment at mu opioid receptor-1 (unknown origin) expressed in CHO cells preincubated for 30 mins followed by DAMGO addition measured after 90 mins by beta-galactosidase complementation assay
[PMID: 27556704]
CHO IC50
61 nM
Compound: 3; Mitragynine Pseudoindoxyl
Antagonist activity at mouse delta opioid receptor-1 expressed in CHO cell membranes assessed as inhibition of DPDPE-induced [35S]GTPgammaS binding incubated for 60 mins by scintillation spectroscopic analysis
Antagonist activity at mouse delta opioid receptor-1 expressed in CHO cell membranes assessed as inhibition of DPDPE-induced [35S]GTPgammaS binding incubated for 60 mins by scintillation spectroscopic analysis
[PMID: 27556704]
Molecular Weight

414.49

Formula

C23H30N2O5
CAS No.
SMILES

O=C1[C@@]2(NC3=CC=CC(OC)=C31)[C@@]4([H])N(C[C@H]([C@H](C4)/C(C(OC)=O)=C\OC)CC)CC2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Mitragynine pseudoindoxyl Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mitragynine pseudoindoxyl2035457-43-1Opioid ReceptorhYperlocomotionGI transitOxidative MetabolismInhibitorinhibitorinhibit

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