2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. MK-2295

MK-2295 (NGD-8243) is a TRPV1 antagonist. MK-2295 is an analgesic agent, and can be used for research of pain.

For research use only. We do not sell to patients.

MK-2295 Chemical Structure

MK-2295 Chemical Structure

CAS No. : 573678-04-3

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Based on 1 publication(s) in Google Scholar

MK-2295 Related Antibodies

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TRPC TRPM TRPV TRPA TRPML

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Description

MK-2295 (NGD-8243) is a TRPV1 antagonist. MK-2295 is an analgesic agent, and can be used for research of pain[1][2].

IC50 & Target

TRPV1

 

Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
1.1 nM
Compound: 6a
Antagonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of capsazepine-induced calcium mobilization by FLIPR assay
Antagonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of capsazepine-induced calcium mobilization by FLIPR assay
[PMID: 20307063]
Molecular Weight

434.34

Formula

C21H12F6N4
CAS No.
SMILES

C1=CC(=C(N=C1)C2=CC3=C(C=C2)C(=NC=N3)NC4=CC=C(C=C4)C(F)(F)F)C(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MK-2295 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MK-2295573678-04-3NGD-8243MK2295MK 2295NGD8243NGD 8243TRP ChannelTransient receptor potential channelsanalgesicInhibitorinhibitorinhibit

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