2. MAPK/ERK Pathway Apoptosis
  3. MNK Apoptosis
  4. MNK1/2-IN-6

MNK1/2-IN-6 is a potent and selective MNK1/2 inhibitor with IC50s of 2.3 nM and 3.4 nM for MNK1 and MNK2, respectively. MNK1/2-IN-6 induces apoptosis in a concentration-dependent manner.

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MNK1/2-IN-6 Chemical Structure

MNK1/2-IN-6 Chemical Structure

CAS No. : 2771087-94-4

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MNK1/2-IN-6 Related Antibodies

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Description

MNK1/2-IN-6 is a potent and selective MNK1/2 inhibitor with IC50s of 2.3 nM and 3.4 nM for MNK1 and MNK2, respectively. MNK1/2-IN-6 induces apoptosis in a concentration-dependent manner[1].

IC50 & Target[1]

MNK1

2.3 nM (IC50)

MNK2

3.4 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
DOHH-2 IC50
0.4092 μM
Compound: II-5
Antiproliferative activity against human DOHH-2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human DOHH-2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33971490]
TMD8 IC50
0.3896 μM
Compound: II-5
Antiproliferative activity against human TMD8 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human TMD8 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33971490]
In Vitro

MNK1/2-IN-6 (compound II-5) (72 h) shows antiproliferative activity with IC50s of 0.3896µM, 0.4092 µM for TMD-8, DOHH-2 cells, respectively[1].
MNK1/2-IN-6 (0.25, 0.5, 1 µM; 24 h) induces TMD-8 cells apoptosis in a concentration-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MNK1/2-IN-6 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: TMD-8, DOHH-2 cells
Concentration:
Incubation Time: 72 h
Result: Showed antiproliferative activity with IC50s of 0.39µM, 0.41 µM for TMD-8, DOHH-2 cells, respectively.

Apoptosis Analysis[1]

Cell Line: TMD-8 cells
Concentration: 0.25, 0.5, 1 µM
Incubation Time: 24 h
Result: Induced TMD-8 cells apoptosis in a concentration-dependent manner.
Molecular Weight

448.52

Formula

C27H24N6O
CAS No.
SMILES

N[C@H]1CCCN(C1)C(C2=CC=C(C=C2)C3=NN4C(C5=CC=C6C=NC=CC6=C5)=CN=C4C=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MNK1/2-IN-6 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MNK1/2-IN-62771087-94-4MNKApoptosisMitogen activated protein kinase interacting kinaseMAP kinase interacting kinaseMAPK interacting kinaseSelectiveantiproliferativeTMD-8 cellsDOHH-2 cellsapoptosisInhibitorinhibitorinhibit

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