2. PROTAC PI3K/Akt/mTOR
  3. PROTACs Akt
  4. MS21

MS21, a novel degrader of AKT, selectively inhibits the growth of PI3K/PTEN pathway-mutant cancers with wild-type KRAS and BRAF.

For research use only. We do not sell to patients.

MS21 Chemical Structure

MS21 Chemical Structure

CAS No. : 2376137-05-0

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1 mg USD 450 In-stock
5 mg USD 1450 In-stock
10 mg USD 2400 In-stock
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Based on 1 publication(s) in Google Scholar

MS21 Related Antibodies

Top Publications Citing Use of Products

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Akt Akt1 Akt2 Akt3

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Description

MS21, a novel degrader of AKT, selectively inhibits the growth of PI3K/PTEN pathway-mutant cancers with wild-type KRAS and BRAF.

Molecular Weight

1107.84

Formula

C58H79ClN12O6S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NC1(CCN(C2=NC=NC3=C2C=CN3)CC1)C(N[C@@H](CCN4CCN(C(CCCCCCCCCC(N[C@@H](C(C)(C)C)C(N5C[C@H](O)C[C@H]5C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)=O)=O)=O)CC4)C8=CC=C(Cl)C=C8)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

Methanol : 95 mg/mL (85.75 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9027 mL 4.5133 mL 9.0266 mL
5 mM 0.1805 mL 0.9027 mL 1.8053 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.88%

COA (248 KB) HNMR (227 KB) LCMS (97 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Methanol 1 mM 0.9027 mL 4.5133 mL 9.0266 mL 22.5664 mL
5 mM 0.1805 mL 0.9027 mL 1.8053 mL 4.5133 mL
10 mM 0.0903 mL 0.4513 mL 0.9027 mL 2.2566 mL
15 mM 0.0602 mL 0.3009 mL 0.6018 mL 1.5044 mL
20 mM 0.0451 mL 0.2257 mL 0.4513 mL 1.1283 mL
25 mM 0.0361 mL 0.1805 mL 0.3611 mL 0.9027 mL
30 mM 0.0301 mL 0.1504 mL 0.3009 mL 0.7522 mL
40 mM 0.0226 mL 0.1128 mL 0.2257 mL 0.5642 mL
50 mM 0.0181 mL 0.0903 mL 0.1805 mL 0.4513 mL
60 mM 0.0150 mL 0.0752 mL 0.1504 mL 0.3761 mL
80 mM 0.0113 mL 0.0564 mL 0.1128 mL 0.2821 mL
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MS21 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MS212376137-05-0MS 21MS-21PROTACsAktPKBProtein kinase BInhibitorinhibitorinhibit

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