Mtb-cyt-bd oxidase-IN-7 

Mtb-cyt-bd oxidase-IN-7 is a cytochrome bd terminal oxidase (Cyt-bd) inhibitor with a K_d value of 4.17 μM. Mtb-cyt-bd oxidase-IN-7 shows anti-tuberculosis activities^[1].

Mtb-cyt-bd oxidase-IN-7 (compound 8d) is a 1-hydroxy-2-methylquinolin-4(1H)-one derivative. Mtb-cyt-bd oxidase-IN-7 inhibits the growth of the cytochrome bcc-aa3 oxidase (Cyt-bcc) knock-out strain (ΔqcrCAB, Cyt-bd⁺) with a MIC value of 6.25 μM. The combination of Mtb-cyt-bd oxidase-IN-7 with the Cyt-bcc inhibitor Q203 completely inhibited oxygen consumption of the wild-type strain and the inverted-membrane vesicles expressing M. tuberculosis Cyt-bd (ΔcydAB::MtbCydAB⁺)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

333.30

C₁₈H₁₄F₃NO₂

CC1=C(C(C2=CC=CC=C2N1O)=O)CC3=CC=C(C=C3)C(F)(F)F

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Yang Zhou, et al. Discovery of 1-hydroxy-2-methylquinolin-4(1H)-one derivatives as new cytochrome bd oxidase inhibitors for tuberculosis therapy. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114896.  [Content Brief]