MTP

Cat. No.: HY-155785: FAQs
Data Sheet Handling Instructions

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MTP is a PKM2 inhibitor. MTP induces cancer cell apoptosis by modulating caspase-3 activation. MTP induces autophagy and increases ROS generation. MTP also inhibits JAK2 signaling. MTP can be used for research of oral squamous cell carcinoma.

For research use only. We do not sell to patients.

MTP Chemical Structure

CAS No. : 2377372-62-6

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JAK1 JAK2 JAK3 Tyk2 JAK

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

JAK2

Cellular Effect

Cell Line	Type	Value	Description	References
LNCaP	IC₅₀	> 2 μM Compound: 1; Tr-87	Antiproliferative activity against human LNCAP cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human LNCAP cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31465224]
MCF7	IC₅₀	1 μM Compound: 1; Tr-87	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31465224]
MDA-MB-231	IC₅₀	0.1 μM Compound: 1; Tr-87	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31465224]
NCI-H157	IC₅₀	> 2 μM Compound: 1; Tr-87	Antiproliferative activity against human NCI-H157 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human NCI-H157 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31465224]
NCI-H157	IC₅₀	> 2 μM Compound: 1; Tr-87	Antiproliferative activity against human NCI-H157 cells expressing wild type EGFR assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human NCI-H157 cells expressing wild type EGFR assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31465224]
NCI-H1650	IC₅₀	0.2 μM Compound: 1; Tr-87	Antiproliferative activity against human NCI-H1650 cells harboring EGFR mutant assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human NCI-H1650 cells harboring EGFR mutant assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31465224]
NCI-H1975	IC₅₀	1 μM Compound: 1; Tr-87	Antiproliferative activity against human NCI-H1975 cells harboring EGFR mutant assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human NCI-H1975 cells harboring EGFR mutant assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31465224]
NCI-H460	IC₅₀	1.5 μM Compound: 1; Tr-87	Antiproliferative activity against human H460 cells expressing wild type EGFR assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human H460 cells expressing wild type EGFR assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31465224]
PC-3	IC₅₀	0.6 μM Compound: 1; Tr-87	Antiproliferative activity against human PC3 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human PC3 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31465224]
PC-9	IC₅₀	0.5 μM Compound: 1; Tr-87	Antiproliferative activity against human PC9 cells harboring EGFR mutant assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human PC9 cells harboring EGFR mutant assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31465224]

Molecular Weight

516.51

Formula

C₂₉H₂₃F₃N₄O₂

CAS No.

2377372-62-6

SMILES

C#CC(NC1=CC=C(C=C1)N2N=C(C=C2C3=CC=C(C=C3)C4=CC=C(C=C4)C(F)(F)F)CCC(NC)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Weng JR, et al. A PKM2 inhibitor induces apoptosis and autophagy through JAK2 in human oral squamous cell carcinoma cells. Chem Biol Interact. 2023 Aug 1;380:110538. [Content Brief]

MTP Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MTP2377372-62-6AutophagyReactive Oxygen SpeciesApoptosisJAKJanus kinaseanticancerOSCCoral squamous cell carcinomaHSC-3JAK2 signalingInhibitorinhibitorinhibit

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