2. PROTAC
  3. PROTAC Linkers
  4. N-(Azido-PEG2)-N-bis(PEG4-Boc)

N-(Azido-PEG2)-N-bis(PEG4-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Azido-PEG2)-N-bis(PEG4-Boc) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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N-(Azido-PEG2)-N-bis(PEG4-Boc) Chemical Structure

N-(Azido-PEG2)-N-bis(PEG4-Boc) Chemical Structure

CAS No. : 2112731-81-2

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N-(Azido-PEG2)-N-bis(PEG4-Boc) Related Antibodies

Top Publications Citing Use of Products

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

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Description

N-(Azido-PEG2)-N-bis(PEG4-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Azido-PEG2)-N-bis(PEG4-Boc) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

N-(Azido-PEG2)-N-bis(PEG4-Boc) Related Antibodies
Molecular Weight

782.96

Formula

C36H70N4O14
CAS No.
Appearance

Viscous Liquid

Color

Colorless to light yellow

SMILES

O=C(CCOCCOCCOCCOCCN(CCOCCOCCOCCOCCC(OC(C)(C)C)=O)CCOCCOCCN=[N+]=[N-])OC(C)(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation
References
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N-(Azido-PEG2)-N-bis(PEG4-Boc) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-(Azido-PEG2)-N-bis(PEG4-Boc)2112731-81-2PROTAC LinkersInhibitorinhibitorinhibit

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