2. PROTAC
  3. PROTAC Linkers
  4. N-(Boc-PEG1)-N-bis(PEG2-propargyl)

N-(Boc-PEG1)-N-bis(PEG2-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Boc-PEG1)-N-bis(PEG2-propargyl) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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N-(Boc-PEG1)-N-bis(PEG2-propargyl) Chemical Structure

N-(Boc-PEG1)-N-bis(PEG2-propargyl) Chemical Structure

CAS No. : 2100306-63-4

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N-(Boc-PEG1)-N-bis(PEG2-propargyl) Related Antibodies

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

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Description

N-(Boc-PEG1)-N-bis(PEG2-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Boc-PEG1)-N-bis(PEG2-propargyl) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

N-(Boc-PEG1)-N-bis(PEG2-propargyl) Related Antibodies
Molecular Weight

456.57

Formula

C23H40N2O7
CAS No.
Appearance

Viscous Liquid

Color

Colorless to light yellow

SMILES

C#CCOCCOCCN(CCOCCOCC#C)CCOCCNC(OC(C)(C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation
References
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N-(Boc-PEG1)-N-bis(PEG2-propargyl) Related Classifications

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-(Boc-PEG1)-N-bis(PEG2-propargyl)2100306-63-4PROTAC LinkersInhibitorinhibitorinhibit

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